phenobarbital will reduce the extent or result of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Sturdy or reasonable CYP3A4 inducers could increase price of diazepam elimination; hence, efficacy of diazepam could be reduced.Barbiturates are metabolized largely via the hepatic microsomal enzyme